The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 02, 2021

Filed:

Aug. 01, 2019
Applicant:

Theranos Ip Company, Llc, Healdsburg, CA (US);

Inventors:

Xinwei Sam Gong, Mountain View, CA (US);

Daniel Young, San Francisco, CA (US);

William Westrick, Palo Alto, CA (US);

Assignee:

Labrador Diagnostics LLC, Wilmington, DE (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); G01N 21/64 (2006.01); G01N 35/00 (2006.01); G01N 21/03 (2006.01); G01N 21/27 (2006.01);
U.S. Cl.
CPC ...
B01L 3/508 (2013.01); G01N 21/03 (2013.01); G01N 21/27 (2013.01); G01N 21/6428 (2013.01); G01N 35/00 (2013.01); B01L 2200/023 (2013.01); B01L 2300/047 (2013.01); B01L 2300/0609 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0832 (2013.01); B01L 2300/0848 (2013.01); G01N 2021/036 (2013.01); G01N 2021/6439 (2013.01); G01N 2035/00237 (2013.01);
Abstract

Devices, methods and systems are provided for reducing the sample volume required for analysis. Inserts placed within a sample container, and substitute sample containers having smaller volume sample chambers are provided. Methods are provided for detection and quantification of target substances in reduced volume samples. Methods include placing a small-volume of sample in a small-volume insert. Methods include diluting a small-volume sample, and placing the diluted sample in a small-volume insert. Methods include reducing the volume of sample, and: increasing illumination; increasing dye concentration or amount; increasing the amount of an enzyme substrate; increasing the amounts, concentration, or labeling of antibodies for detection; increasing optical detector sensitivity; increasing the path length of light passing through the sample; decreasing the separation between sample and detector; altering the wavelength, or polarization, or number of wavelengths, passing through the sample; increasing electronic amplification of electrical signals; altering assay temperature; and other alterations.


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