The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2021
Filed:
Jul. 05, 2018
Monash University, Clayton, AU;
Memorial Sloan-kettering Cancer Centre, New York, NY (US);
Ludwig Institute for Cancer Research Ltd., New York, NY (US);
Olivia Newton-john Cancer Research Institute, Heidelberg, AU;
Beate Lackmann, St. Andrews Beach, AU;
Martin Lackmann, St. Andrews Beach, AU;
Peter W. Janes, Hawthorn East, AU;
Lakmali Atapattu Mudiyanselage, Hughesdale, AU;
Andrew M. Scott, Krew East, AU;
Dimitar B. Nikolov, New York, NY (US);
Nayanendu Saha, Jackson Heights, NY (US);
Monash University, Clayton, AU;
Memorial Sloan-Kettering Cancer Centre, New York, NY (US);
Ludwig Institute for Cancer Research Ltd., New York, NY (US);
Olivia Newton-John Cancer Research Institute, Heidelberg, AU;
Abstract
Expression of proteolytically active, high molecular weight ADAM10 protease is relatively increased in tumour cells that also express the putative tumour stem cell marker CD133. A recombinant humanized antibody or antibody fragment based on 8C7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight ADAM10 protease to thereby detect tumour cells and also as a therapeutic agent for treating cancers, tumours and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumour, renal tumour, prostate cancer, sarcoma and/or melanoma.