The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2021
Filed:
Dec. 03, 2018
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Ivan M. Borrello, Baltimore, MD (US);
Kimberly A. Noonan, Baltimore, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); A61K 35/17 (2015.01); A61P 35/00 (2006.01); C12N 5/0783 (2010.01); C12N 5/077 (2010.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61P 35/00 (2018.01); C12N 5/0636 (2013.01); C12N 5/0669 (2013.01); A61K 2035/124 (2013.01); C12N 2500/02 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/998 (2013.01);
Abstract
In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes ('MILs'). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.