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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11160808 B1

PDFFull Text
Date of Patent:
Nov. 02, 2021

Filed:

Jul. 22, 2019

Compounds that enhance atoh1 expression

Applicants:

Massachusetts Eye & Ear Infirmary, Boston, MA (US);

The Brigham & Women's Hospital, Inc., Boston, MA (US);

Inventors:

Albert Edge, Brookline, MA (US);

Sang-Jun Jeon, Seoul, KR;

Kathleen Seyb, Allston, MA (US);

Marcie Glicksman, Winchester, MA (US);

Lixin Qiao, Tewksbury, MA (US);

Gregory D. Cuny, Houston, TX (US);

Assignees:

Massachusetts Eye & Ear Infirmary, Boston, MA (US);

Brigham & Women's Hospital, Inc., Boston, MA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Craig D Ricci

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/415 (2006.01); A61K 31/423 (2006.01); A61K 31/4245 (2006.01); A61K 31/426 (2006.01); A61K 31/428 (2006.01); A61K 31/341 (2006.01); A61K 31/4184 (2006.01); A61K 9/00 (2006.01); A61K 31/353 (2006.01); A61K 31/4436 (2006.01); A61K 31/496 (2006.01); A61K 31/498 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 35/28 (2015.01); A61K 35/545 (2015.01); A61K 31/352 (2006.01); A61K 31/404 (2006.01); A61K 31/4155 (2006.01); A61K 31/4192 (2006.01); A61K 31/4365 (2006.01); A61K 31/437 (2006.01); A61K 31/44 (2006.01); A61K 31/4439 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 9/0046 (2013.01); A61K 31/341 (2013.01); A61K 31/343 (2013.01); A61K 31/352 (2013.01); A61K 31/353 (2013.01); A61K 31/381 (2013.01); A61K 31/404 (2013.01); A61K 31/415 (2013.01); A61K 31/4155 (2013.01); A61K 31/4184 (2013.01); A61K 31/4192 (2013.01); A61K 31/423 (2013.01); A61K 31/426 (2013.01); A61K 31/428 (2013.01); A61K 31/4245 (2013.01); A61K 31/437 (2013.01); A61K 31/4365 (2013.01); A61K 31/44 (2013.01); A61K 31/4436 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 31/498 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 35/28 (2013.01); A61K 35/545 (2013.01);
Abstract

This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

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