The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 26, 2021

Filed:

Jan. 19, 2018
Applicant:

Arizona Board of Regents, on Behalf of Arizona State University, Scottsdale, AZ (US);

Inventors:

Liqiang Zhang, Chandler, AZ (US);

Xiangxing Kong, Tempe, AZ (US);

Yanqing Tian, Tempe, AZ (US);

Deirdre Meldrum, Phoenix, AZ (US);

Fengyu Su, Tempe, AZ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 21/64 (2006.01); G01N 33/84 (2006.01); C07D 471/16 (2006.01); C08F 220/58 (2006.01); C12Q 1/02 (2006.01); G01N 31/22 (2006.01); G01N 33/50 (2006.01); G01N 21/77 (2006.01);
U.S. Cl.
CPC ...
G01N 33/84 (2013.01); C07D 471/16 (2013.01); C08F 220/58 (2013.01); C12Q 1/02 (2013.01); G01N 21/64 (2013.01); G01N 21/6428 (2013.01); G01N 31/221 (2013.01); G01N 33/5005 (2013.01); G01N 2021/6439 (2013.01); G01N 2021/7786 (2013.01);
Abstract

Fluorescent pH sensors are provided. The fluorescent pH sensor comprises a copolymer for sensing pH and a polymerized form of N-(2-hydroxypropyl)methacrylamide (HPMA) or 2-hydroxyethyl methacrylate (HEMA). The probe for sensing pH has formula (I): wherein Rand Rare as defined herein. The fluorescent pH sensors may be used in determining the pH of a sample and detecting extracellular pH in a sample. Methods for preparing the fluorescent pH sensors and the probe for sensing pH are also provided.


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