The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
Jan. 17, 2014
Takeda Pharmaceutical Company Limited, Osaka, JP;
Daniel J. Sexton, Melrose, MA (US);
Ryan Faucette, Melrose, MA (US);
Jon A. Kenniston, Hingham, MA (US);
Gregory P. Conley, Arlington, MA (US);
Andrew Nixon, Hanover, MA (US);
Christopher TenHoor, Hopkinton, MA (US);
Burt Adelman, Concord, MA (US);
Yung Chyung, Lexington, MA (US);
Takeda Pharmaceutical Company Limited, Osaka, JP;
Abstract
The present disclosure provides methods of evaluating a subject, e.g., a subject at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder, based on values (e.g., percentages) of intact and/or cleaved kininogen in a sample of the subject. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment. Such methods can involve the use of a detection agent that preferentially binds cleaved kininogen or intact kininogen.