The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
Sep. 07, 2017
Sanofi Pasteur Vaxdesign Corporation, Orlando, FL (US);
Evan Gomes, Orlando, FL (US);
Tirumalai Kamala, Orlando, FL (US);
Luis Mosquera, Orlando, FL (US);
Vaughan Wittman, Napa, CA (US);
William Warren, Orlando, FL (US);
Janice Moser, Orlando, FL (US);
Donald Drake, Orlando, FL (US);
SANOFI PASTEUR VAXDESIGN CORPORATION, Orlando, FL (US);
Abstract
In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicular helper cells and B cells, and one comprising cord blood-derived dendritic cells and CD4+ T cells. The models can be used, for example, to assess candidate vaccines via analysis of cellular responses to antigen and vaccine exposure.