The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
May. 08, 2018
Applicant:
Roche Innovation Center Copenhagen A/s, Basel, CH;
Inventors:
Nanna Albaek, Birkerod, DK;
Henrik Hansen, Rodovre, DK;
Susanne Kammler, Holte, DK;
Jacob Ravn, Skovlunde, DK;
Henrik Orum, Vaerlose, DK;
Assignee:
Roche Innovation Center Copenhagen A/S, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 15/111 (2013.01); C12N 2310/11 (2013.01); C12N 2310/314 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/341 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3515 (2013.01); C12N 2310/3517 (2013.01); C12N 2320/32 (2013.01); C12N 2330/30 (2013.01);
Abstract
The invention relates to the field of oligonucleotide therapeutics, and in particular to the use of a cleavable, e.g. a phosphodiester region covalently attached to a conjugate, a targeting group or blocking group to enhance the properties of the oligonucleotides, for example to improve the therapeutic index.