The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 26, 2021

Filed:

Jan. 24, 2019
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Philipp S. Spuhler, Boston, MA (US);

Kyle C. Smith, Cambridge, MA (US);

Fabio Fachin, Cambridge, MA (US);

Thomas Alan Barber, Sudbury, MA (US);

Ravi Kapur, Sharon, MA (US);

Mehmet Toner, Charlestown, MA (US);

Vincent Pai, Somerville, MA (US);

Nezihi Murat Karabacak, Arlington, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 35/00 (2006.01); C12M 1/00 (2006.01); B03C 1/01 (2006.01); G01N 15/14 (2006.01); B01L 3/00 (2006.01); B03C 1/033 (2006.01); B03C 1/28 (2006.01); G01N 1/00 (2006.01); C12M 3/06 (2006.01); G01N 15/10 (2006.01); G01N 35/10 (2006.01); C12M 1/42 (2006.01);
U.S. Cl.
CPC ...
C12M 47/04 (2013.01); B01L 3/00 (2013.01); B01L 3/502753 (2013.01); B01L 3/502761 (2013.01); B03C 1/01 (2013.01); B03C 1/0332 (2013.01); B03C 1/288 (2013.01); C12M 23/16 (2013.01); G01N 1/00 (2013.01); G01N 15/1463 (2013.01); G01N 35/0098 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/086 (2013.01); B03C 2201/18 (2013.01); B03C 2201/22 (2013.01); B03C 2201/26 (2013.01); C12M 35/06 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/149 (2013.01); G01N 2035/00237 (2013.01); G01N 2035/1034 (2013.01);
Abstract

Microfluidic devices are described that include a microfluidic channel, a first array of one or more magnets above the microfluidic channel, each magnet in the first array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the first array, and a second array of one or more magnets beneath the microfluidic channel, each magnet in the second array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the second array. The first array is aligned with respect to the second array such that magnetic fields emitted by the first array and second array generate a magnetic flux gradient profile extending through the channel. An absolute value of the profile includes a first maximum and a second maximum that bound a local minimum. The local minimum is located within the microfluidic channel or less than 5 mm away from a wall of the microfluidic channel. Methods of using the new devices are also described.


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