The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 26, 2021

Filed:

May. 17, 2016
Applicants:

Five Prime Therapeutics, Inc., South San Francisco, CA (US);

Eureka Therapeutics, Inc., Emeryville, CA (US);

Inventors:

Brian Wong, South San Francisco, CA (US);

Emma Masteller, South San Francisco, CA (US);

Cheng Liu, Emeryville, CA (US);

Yiyang Xu, Emeryville, CA (US);

Hong Liu, Emeryville, CA (US);

Su Yan, Emeryville, CA (US);

Jingyi Xiang, Emeryville, CA (US);

Pei Wang, Emeryville, CA (US);

Assignee:

EUREKA THERAPEUTICS, INC., Emeryville, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/28 (2006.01); A61K 51/10 (2006.01); A61K 47/68 (2017.01); A61P 35/02 (2006.01); A61P 35/00 (2006.01); A61K 38/05 (2006.01); C07K 16/00 (2006.01); G01N 33/574 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 38/05 (2013.01); A61K 47/6817 (2017.08); A61K 47/6851 (2017.08); A61K 47/6881 (2017.08); A61K 51/1027 (2013.01); A61K 51/1042 (2013.01); A61K 51/1096 (2013.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07K 16/005 (2013.01); C07K 16/2809 (2013.01); C07K 16/30 (2013.01); G01N 33/57492 (2013.01); A61K 2039/505 (2013.01); C07K 2317/14 (2013.01); C07K 2317/21 (2013.01); C07K 2317/31 (2013.01); C07K 2317/34 (2013.01); C07K 2317/52 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); G01N 2333/912 (2013.01);
Abstract

The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.


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