The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
Sep. 25, 2019
Taipei Medical University, Taipei, TW;
National Taipei University of Technology, Taipei, TW;
Chun-Mao Lin, Taipei, TW;
Chi-Ming Lee, Taipei, TW;
Chi Wang, Taipei, TW;
Sheng-Tung Huang, Taipei, TW;
Jiun-An Gu, Taipei, TW;
Tin-An Rau, Taipei, TW;
TAIPEI MEDICAL UNIVERSITY, Taipei, TW;
NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY, Taipei, TW;
Abstract
The present invention provides RUT analogs with various biological activities. In particular, the biological activities comprise anti-inflammatory activity, vasodilator effects, migration/invasion-suppressive activities, ability against damage due to remodeling between the epithelium and endothelium, collagen deposition and cardiac fibrosis suppress, Snail protein inhibitory effect, etc., which may improve cardiac, vasodilation, and lung functions. The RUT analogs disclosed herein also exhibit a lower cytotoxicity comparing to RUT.