IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11155525 B1

PDFFull Text
Date of Patent:
Oct. 26, 2021

Filed:

Apr. 20, 2020

Azole derivatives as apelin receptor agonist

Applicant:

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US);

Inventors:

Takuya Ikeda, Tokyo, JP;

Yoshiyuki Kobayashi, Tokyo, JP;

Naoki Miyoshi, Tokyo, JP;

Osamu Suzuki, Tokyo, JP;

Takahiro Nagayama, Tokyo, JP;

Takashi Tsuji, Tokyo, JP;

Layton H. Smith, Orlando, FL (US);

Anthony B. Pinkerton, Rancho Santa Fe, CA (US);

Assignee:

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, La Jolla, CA (US);

Attorney:

Wilson Sonsini Goodrich & Rosati

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
C07D 249/12 (2006.01); G16B 25/00 (2019.01); G16C 99/00 (2019.01); C07D 403/12 (2006.01); C07D 403/06 (2006.01); G16C 20/50 (2019.01); A61P 9/10 (2006.01); A61P 3/10 (2006.01); A61P 9/12 (2006.01); A61P 13/12 (2006.01); A61P 9/04 (2006.01); C07D 401/04 (2006.01); C07D 405/04 (2006.01); C07D 405/14 (2006.01); C07D 409/04 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 249/12 (2013.01); A61P 3/10 (2018.01); A61P 9/04 (2018.01); A61P 9/10 (2018.01); A61P 9/12 (2018.01); A61P 13/12 (2018.01); C07D 401/04 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01); G16B 25/00 (2019.02); G16C 20/50 (2019.02); G16C 99/00 (2019.02);
Abstract

The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein Xrepresents —N═ or —CH═, Xrepresents —CH═ or —N═, Rand Reach represent a Cto Calkoxy group or the like, Rrepresents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and Rrepresents a Cto Calkylthio group or a Cto Calkenyl group (the Cto Calkylthio group and the Cto Calkenyl group are each optionally substituted by one carboxy group or the like) or the like.

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