The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
Apr. 23, 2018
Otsuka Pharmaceutical Factory, Inc., Tokushima, JP;
Adabio Co., Ltd., Gunma, JP;
Katsuya Hiraishi, Gunma, JP;
Hiroyuki Soma, Gunma, JP;
Fumie Jimma, Gunma, JP;
Taro Adachi, Gunma, JP;
Ippei Yamaoka, Tokushima, JP;
Naoyuki Endo, Tokushima, JP;
OTSUKA PHARMACEUTICAL FACTORY, INC., Tokushima, JP;
ADABIO CO., LTD., Gunma, JP;
Abstract
By using ion exchange column chromatography or calcium carbonate to an aqueous solution containing a compound A represented by the following formula and citric acid, citric acid in the aqueous solution is removed and a crystalline compound A is obtained by being thereafter subjected to several steps. Further a high-purity noncrystalline compound A is obtained by using calcium carbonate, sulfuric acid, an organic solvent and the like to the aqueous solution containing the compound A and citric acid to remove citric acid and the crystalline compound A in the solution. The configuration of the crystalline compound A is an SS isomer in the RS notation system. The configuration of the noncrystalline compound A is an SR isomer.