The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
Feb. 24, 2021
Ascendis Pharma Growth Disorders A/s, Hellerup, DK;
Harald Rau, Dossenheim, DE;
Ulrich Hersel, Heidelberg, DE;
Felix Cleemann, Mainz, DE;
Caroline Elisabeth Rasmussen, Virum, DK;
ASCENDIS PHARMA GROWTH DISORDERS A/S, Hellerup, DK;
Abstract
The present invention relates to a CNP prodrug or a pharmaceutically acceptable salt thereof comprising a CNP moiety -D; and a carrier moiety —Z that is conjugated through a moiety -L- to a reversible prodrug linker moiety -L-, which reversible prodrug linker moiety -L- is covalently and reversibly conjugated to -D; wherein -L- is a chemical bond or a spacer; and —Z is a polymer having a molecular weight of at least 10 kDa. It further relates to pharmaceutical compositions comprising the CNP prodrug or a pharmaceutically acceptable salt thereof, their use as a medicament and to methods of treatment.