The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
Apr. 17, 2019
Applicant:
Elysium Therapeutics, Inc., Danville, CA (US);
Inventor:
Thomas E. Jenkins, Half Moon Bay, CA (US);
Assignee:
ELYSIUM THERAPEUTICS, INC., Danville, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/485 (2006.01); A61K 47/64 (2017.01); A61K 47/61 (2017.01); A61K 47/55 (2017.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/485 (2013.01); A61K 45/06 (2013.01); A61K 47/55 (2017.08); A61K 47/61 (2017.08); A61K 47/64 (2017.08);
Abstract
The invention provides pharmaceutical compositions comprising macromolecular gastrointestinal enzyme-labile opioid prodrugs, co-formulated with small-molecule and/or macromolecular gastrointestinal enzyme inhibitors. The macromolecular constructs are minimally absorbed from the GI tract, and can produce non-linear pharmacokinetic profiles of the delivered opioid agonist following oral ingestion. An optional macromolecular opioid antagonist may also be present in compositions of the invention to discourage tampering by potential abusers.