The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2021
Filed:
Apr. 08, 2016
Medical Research Council, Swindon, GB;
Anne Bertolotti, Cambridge, GB;
Indrajit Das, Cambridge, GB;
Agnieszka Krzyzosiak, Cambridge, GB;
Adrien Rousseau, Cambridge, GB;
Kim Schneider, Cambridge, GB;
Anna Gudny Sigurdardottir, Cambridge, GB;
United Kingdom Research and Innovation, Swindon, GB;
Abstract
The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R, R, R, Xand Yare as defined herein.