The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 19, 2021

Filed:

May. 26, 2016
Applicant:

Creatv Microtech Inc., Potomac, MD (US);

Inventors:

Daniel Adams, Basking Ridge, NJ (US);

Cha-Mei Tang, Potomac, MD (US);

Assignee:

Creatv Microtech, Inc., Potomac, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/574 (2013.01); G01N 33/5005 (2013.01); G01N 33/5091 (2013.01); G01N 33/5743 (2013.01); G01N 33/57415 (2013.01); G01N 33/57423 (2013.01); G01N 33/57434 (2013.01); G01N 33/57438 (2013.01); G01N 33/57446 (2013.01); G01N 2800/52 (2013.01); G01N 2800/56 (2013.01); G01N 2800/7028 (2013.01);
Abstract

Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.


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