The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 19, 2021

Filed:

Nov. 19, 2019
Applicants:

International Business Machines Corporation, Armonk, NY (US);

Agency for Science, Technology and Research, Singapore, SG;

Inventors:

Kazuki Fukushima, Yamagata, JP;

James L. Hedrick, Pleasanton, CA (US);

Yi Yan Yang, Singapore, SG;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/34 (2017.01); C12N 15/88 (2006.01); C08G 63/64 (2006.01); C08G 63/91 (2006.01); C08G 64/02 (2006.01); C08G 64/42 (2006.01); C08G 63/06 (2006.01); C08G 64/38 (2006.01); C12N 5/00 (2006.01); C08G 64/18 (2006.01); C08G 64/30 (2006.01);
U.S. Cl.
CPC ...
C08G 63/64 (2013.01); A61K 47/34 (2013.01); C08G 63/06 (2013.01); C08G 63/912 (2013.01); C08G 64/0208 (2013.01); C08G 64/0241 (2013.01); C08G 64/18 (2013.01); C08G 64/30 (2013.01); C08G 64/38 (2013.01); C08G 64/42 (2013.01); C12N 5/0068 (2013.01); C12N 15/88 (2013.01); C08G 2261/126 (2013.01); C12N 2533/30 (2013.01); Y02P 20/582 (2015.11);
Abstract

A biodegradable cationic polymer is disclosed, comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a subunit derived from a monomeric diol initiator for the ring-opening polymerization; and an optional endcap group. The biodegradable cationic polymers have low cytotoxicity and form complexes with biologically active materials useful in gene therapeutics and drug delivery.


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