The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2021
Filed:
Dec. 07, 2017
Applicants:
California Institute of Technology, Pasadena, CA (US);
The Rockefeller University, New York, NY (US);
Inventors:
Ron Diskin, Pasadena, CA (US);
Anthony P. West, Pasadena, CA (US);
Michel C. Nussenzweig, New York, NY (US);
Pamela J. Bjorkman, La Canada, CA (US);
Assignees:
THE ROCKEFELLER UNIVERSITY, New York, NY (US);
CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/10 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1063 (2013.01); C07K 16/1045 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); A61K 2039/545 (2013.01); C07K 2317/567 (2013.01); C07K 2317/76 (2013.01); C12N 2740/16111 (2013.01); C12N 2740/16122 (2013.01);
Abstract
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.