Thrombospondin 1-binding peptide

Abstract

Provided is a compound that can promote angiogenesis by inhibiting the function of TSP1, and is useful for the treatment or prophylaxis of diseases such as critical limb ischemia. Specifically provided is a macrocyclic polypeptide represented by formula (I) [wherein A is selected from the linking groups Ato A; Xis a residue of an aliphatic amino acid, an aromatic amino acid, a basic amino acid, a neutral amino acid, or an acidic amino acid, or is absent; Xis a residue of an aromatic amino acid or a neutral amino acid; Xis a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid; Xis Ser, Thr, Ala, orS; Xis Gly or Ser; Xis a residue of a basic amino acid or a neutral amino acid; Xis a residue of a neutral amino acid or an acidic amino acid; Xis a residue of an aromatic amino acid; Xis a residue of an aliphatic amino acid, a neutral amino acid, or an aromatic amino acid; Xis a residue of a basic amino acid, an aliphatic amino acid, an aromatic amino acid, or a neutral amino acid; Xis a residue of an aromatic amino acid; and Xis a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid], or a pharmacologically acceptable salt thereof.