The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2021
Filed:
Nov. 13, 2020
Applicant:
Hanmi Pharm. Co., Ltd., Hwaseong-si, KR;
Inventors:
Sung Youb Jung, Suwon-si, KR;
Yong Ho Huh, Seoul, KR;
Sung Hee Park, Seongnam-si, KR;
Jong Soo Lee, Seongnam-si, KR;
In Young Choi, Yongin-si, KR;
Assignee:
HANMI PHARM. CO., LTD., Hwaseong-si, KR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); A61K 47/68 (2017.01); C07K 14/47 (2006.01); A61K 47/60 (2017.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 38/193 (2013.01); A61K 47/60 (2017.08); A61K 47/68 (2017.08); A61K 47/6813 (2017.08); A61K 47/6849 (2017.08); C07K 14/47 (2013.01); C07K 16/2803 (2013.01); C07K 2317/40 (2013.01); C07K 2317/52 (2013.01); C07K 2317/53 (2013.01); C07K 2317/94 (2013.01); C07K 2319/30 (2013.01);
Abstract
A modified IgG4 Fc fragment useful as a drug carrier is disclosed. When coupled to a drug, the resulting drug-IgG4 Fc conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.