The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2021
Filed:
Dec. 19, 2012
Pfizer Inc., New York, NY (US);
Kimberly Marquette, Somerville, MA (US);
Eric Bennett, Arlington, MA (US);
Lioudmila Tchistiakova, Andover, MA (US);
L. Nathan Tumey, Pawcatuck, CT (US);
Jack Bikker, Little Silver, NJ (US);
Valerie Calabro, Carro, FR;
Edmund Graziani, Chestnut Ridge, NY (US);
Pfizer Inc., New York, NY (US);
Abstract
The present invention is directed to antibodies, and antigen-binding portions thereof, engineered to introduce amino acids for site-specific conjugation. The invention relates to engineered antibody constant region (Fc, Cγ, Cκ, and Cλ) polypeptides, and portions thereof, and antibodies comprising the polypeptides. Further, the invention relates to Fc fusion proteins comprising an engineered Fc region. The invention also relates to methods and uses of the engineered antibodies and portions for, among other things, production of antibody-drug conjugate therapeutics.