The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2021
Filed:
Jul. 26, 2019
Applicant:
New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery, New York, NY (US);
Inventors:
Alessandra Pernis, Mountain Lakes, NJ (US);
Michela Manni, New York, NY (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/04 (2006.01); A61K 31/7105 (2006.01); C07K 16/30 (2006.01); C12N 15/113 (2010.01); A61P 5/48 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61P 5/48 (2018.01); A61P 35/00 (2018.01); C07K 16/3061 (2013.01); C12N 15/113 (2013.01); C12N 2310/122 (2013.01); C12N 2310/141 (2013.01); C12N 2320/30 (2013.01);
Abstract
This current invention provides methods and agents for preventing and treating autoimmune and lymphoproliferative disease by targeting pathogenic age-associated B cells as well as methods of detecting these pathogenic age-associated B cells as a method of diagnosing and predicting autoimmune disease and other lymphoproliferative and chronic inflammatory disorders. The current invention also provides targets for drug development and basic research for autoimmune diseases and other lymphoproliferative and chronic inflammatory disorders.