The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 19, 2021

Filed:

Jul. 18, 2019
Applicant:

Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);

Inventors:

Jon T. Njardarson, Tucson, AZ (US);

Isaac Chogii, Tucson, AZ (US);

David Townsend Smith, Tucson, AZ (US);

Edon Vitaku, Tucson, AZ (US);

Daniela C. Zarnescu, Tucson, AZ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/404 (2006.01); A61K 31/4025 (2006.01); A61K 31/437 (2006.01); A61P 25/28 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/404 (2013.01); A61K 31/4025 (2013.01); A61K 31/437 (2013.01); A61P 25/28 (2018.01); A61K 45/06 (2013.01);
Abstract

The present invention provides compounds and methods for mitigating a clinical condition associated with a neurodegenerative disease or a locomotor dysfunction in a subject. In one particular aspect, the invention relates to compounds and methods for reducing TDP-43 aggregation or toxicity in a subject. The compounds of the invention include those having the following formulas: or a pharmaceutically acceptable salt thereof wherein


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