The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2021
Filed:
Mar. 20, 2017
Global Life Sciences Solutions Operations Uk Ltd, Sheffield, GB;
Erik Leeming Kvam, Niskayuna, NY (US);
John Richard Nelson, Niskayuna, NY (US);
Gregory Andrew Grossmann, Niskayuna, NY (US);
Ryan Charles Heller, Niskayuna, NY (US);
Erin Jean Finehout, Broomfield, CO (US);
Christopher Michael Puleo, Niskayuna, NY (US);
William Patrick Waters, Niskayuna, NY (US);
Global Life Sciences Solutions Operations UK Ltd, Sheffield, GB;
Abstract
Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-celluar fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.