The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 12, 2021

Filed:

Mar. 03, 2017
Applicant:

The University of Toledo, Toledo, OH (US);

Inventors:

Gayathri Subramanian, Toledo, OH (US);

Mostafa Elsaadany, Toledo, OH (US);

Eda Yildirim-Ayan, Toledo, OH (US);

Assignee:

The University of Toledo, Toledo, OH (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/42 (2006.01); C12M 3/00 (2006.01); C12M 1/12 (2006.01); A61L 27/60 (2006.01); A61L 27/54 (2006.01); A61L 27/24 (2006.01); A61L 27/38 (2006.01); C12N 5/00 (2006.01); C12Q 1/6883 (2018.01); G01N 33/50 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12M 35/04 (2013.01); A61L 27/24 (2013.01); A61L 27/3804 (2013.01); A61L 27/54 (2013.01); A61L 27/60 (2013.01); C12M 3/00 (2013.01); C12M 21/08 (2013.01); C12M 25/14 (2013.01); C12N 5/0012 (2013.01); C12Q 1/6883 (2013.01); G01N 33/5082 (2013.01); C12N 5/0698 (2013.01); C12N 2503/06 (2013.01); C12N 2513/00 (2013.01); C12N 2521/00 (2013.01); C12N 2533/54 (2013.01); C12Q 2600/148 (2013.01); C12Q 2600/158 (2013.01);
Abstract

A scaffold-stretching system includes at least one stretchable loading chamber configured to support a scaffold material and a supply of cells, such as human skin substitute cells, and is configured to allow for cultivation of a cellular three-dimensional scaffold; and a mechanical loading system is configured for application of cyclic and static uniaxial tensile mechanical loading on the cellular three-dimensional scaffold, and is configured to mimic the in vivo environment of musculoskeletal, cardiovascular, and other tissues that experience uniaxial strains.


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