The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2021
Filed:
Oct. 30, 2014
Genzyme Corporation, Cambridge, MA (US);
Eberhard Karls Universität Tübingen, Tübingen, DE;
Gregor Blank, Tübingen, DE;
Rupert Handgretinger, Tübingen, DE;
Karin Schilbach, Tübingen, DE;
Gina Lacorcia, Bridgewater, NJ (US);
Daniel Snell, Thalwil, CH;
Andreas Menrad, Oranienburg, DE;
GENZYME CORPORATION, Cambridge, MA (US);
EBERHARD KARLS UNIVERSITÄT TÜBINGEN, Tübingen, DE;
Abstract
The present disclosure is related to improved methods for use of a humanized binding polypeptide specific for the alpha beta T cell receptor (αβ-TCR). In particular, this disclosure relates to improved methods of use of a humanized anti-αβ-TCR antibody, which is derived from the murine monoclonal antibody BMA031, in immunosuppressive therapy. Novel methods using humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-αβTCR antibodies and/or fragments thereof) are also provided. Novel methods using repetitive administration of humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-αβTCR antibodies and/or fragments thereof) to reduce αβ T cells in the subject relative to γδ cells in the subject are provided.