The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2021
Filed:
Feb. 01, 2018
The Broad Institute, Inc., Cambridge, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Timothy A. Lewis, Cambridge, MA (US);
Xiaoyun Wu, Cambridge, MA (US);
Heidi Greulich, Cambridge, MA (US);
Matthew Meyerson, Boston, MA (US);
Manuel Ellermann, Berlin, DE;
Philip Lienau, Berlin, DE;
Knut Eis, Berlin, DE;
Antje Margret Wengner, Berlin, DE;
Charlotte Christine Kopitz, Falkensee, DE;
Martin Lange, Berlin, DE;
The Broad Institute, Inc., Cambridge, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Abstract
The present invention features improved compounds, especially the compound having the structure (1). Compositions and methods of identifying patients having cancer using biomarkers (e.g., PDE3A, PDE3B, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention.