The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 12, 2021

Filed:

Jun. 12, 2014
Applicant:

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

David A. Weitz, Bolton, MA (US);

Thomas E. Kodger, Cambridge, MA (US);

Donald Aubrecht, Somerville, MA (US);

Ilke Akartuna, Cambridge, MA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B01F 5/06 (2006.01); B01F 13/00 (2006.01); B01J 19/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502784 (2013.01); B01F 5/061 (2013.01); B01F 5/0646 (2013.01); B01F 13/0071 (2013.01); B01J 19/0093 (2013.01); B01L 3/502715 (2013.01); B01F 2005/0631 (2013.01); B01F 2005/0636 (2013.01); B01J 2219/009 (2013.01); B01J 2219/0084 (2013.01); B01J 2219/0086 (2013.01); B01J 2219/00783 (2013.01); B01J 2219/00826 (2013.01); B01J 2219/00828 (2013.01); B01J 2219/00831 (2013.01); B01J 2219/00833 (2013.01); B01J 2219/00855 (2013.01); B01J 2219/00889 (2013.01); B01J 2219/00894 (2013.01); B01J 2219/00896 (2013.01); B01J 2219/00903 (2013.01); B01L 2200/06 (2013.01); B01L 2300/0858 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/12 (2013.01); B01L 2300/161 (2013.01);
Abstract

The present invention generally relates to microfluidics, and, in particular, to systems and methods for coalescing or fusing droplets. In certain aspects, two or more droplets within a microfluidic channel are brought together and caused to coalesce without using electric fields or charges. For example, in certain embodiments, droplets stabilized with a surfactant may be disrupted, e.g., by exposing the droplets to a solvent able to alter the surfactant, which may partially destabilize the droplets and allow them to coalesce. In some instances, the droplets may also be physically disrupted to facilitate coalesce. In addition, in some cases, the positions of one or more droplets may be controlled within a channel using a groove in a wall of the channel. For example, a droplet may at least partially enter the groove such that the position of the droplet is at least partially controlled by the groove.


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