The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 12, 2021

Filed:

Dec. 22, 2015
Applicant:

City of Hope, Duarte, CA (US);

Inventors:

Don J. Diamond, Glendora, CA (US);

Edwin Manuel, Pomona, CA (US);

Assignee:

CITY OF HOPE, Duarte, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 38/47 (2006.01); A61K 45/06 (2006.01); A61K 35/74 (2015.01); A61K 31/337 (2006.01); A61K 31/7068 (2006.01); C12N 15/113 (2010.01); A61P 35/00 (2006.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0025 (2013.01); A61K 31/337 (2013.01); A61K 31/7068 (2013.01); A61K 31/713 (2013.01); A61K 35/74 (2013.01); A61K 38/47 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C12N 15/1137 (2013.01); C12Y 302/01035 (2013.01); C12N 2310/11 (2013.01); C12N 2320/31 (2013.01); C12N 2320/32 (2013.01); Y02A 50/30 (2018.01);
Abstract

Provided herein, inter alia, are compositions and kits comprising a bacterial cell and a tumor penetrating agent. Also provided are methods of treating cancer in a subject including the step of administering to the subject an effective amount of a bacterial cell and a tumor penetrating agent. Provided are methods of stimulating an immune system in a subject. The methods include administering to the subject an effective amount of a bacterial cell and a tumor penetrating agent. Also provided are methods of enhancing delivery of an anti-cancer agent to a tumor cell including the step of contacting the tumor cell with a bacterial cell, a tumor penetrating agent and an anti-cancer agent.


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