The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2021
Filed:
Jul. 05, 2019
Research Foundation of the City University of New York, New York, NY (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Maria Contel, Brooklyn, NY (US);
Natalia Curado, Brooklyn, NY (US);
Jason Lewis, New York, NY (US);
Sophie Poty, New York, NY (US);
Research Foundation of the City University of New York, New York, NY (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Abstract
Antibody-drug-conjugates (ADC) are provided having a structure of: wherein L is PRligand. The ADC has n drug moieties bound to the Trastuzumab antibody such that the ADC has a drug-to-antibody ratio (DAR) between 2 and 4 and the drug moieties are bound to the Trastuzumab antibody through cysteine (S) or lystine (Lys) residues. The disclosed ADCs are particularly useful in treating breast cancer.