The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 12, 2021

Filed:

Mar. 14, 2019
Applicant:

Thermogenesis Corporation, Rancho Cordova, CA (US);

Inventors:

Philip H. Coelho, Rancho Cordova, CA (US);

William Busa, Rancho Cordova, CA (US);

Jonathan Ellis, Rancho Cordova, CA (US);

Dalip Sethi, Rancho Cordova, CA (US);

Assignee:

ThermoGenesis Corporation, Rancho Cordova, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 48/00 (2006.01); A61K 35/17 (2015.01); A61K 47/65 (2017.01); A61K 47/69 (2017.01); C07K 16/18 (2006.01); A61K 9/127 (2006.01); C07K 14/725 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 9/1277 (2013.01); A61K 47/65 (2017.08); A61K 47/6911 (2017.08); C07K 14/7051 (2013.01); C07K 16/18 (2013.01);
Abstract

Disclosed herein are methods for contacting in a closed container a host liquid including target cells, microbubble reagents comprising gas-core lipid-shelled microbubbles, and one or more antibodies or other ligands that bind to cell surface molecules on the target cells, wherein the one or more antibodies or other ligands are bound to the target cells or the microbubbles, wherein the contacting under conditions to produce target cells linked to microbubbles via the one or more antibodies or other ligands and activating the target cells to generate activated target cells.


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