The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2021
Filed:
Jun. 24, 2020
Applicant:
King Abdulaziz University, Jeddah, SA;
Inventors:
Tarek A. Ahmed, Jeddah, SA;
Abdelsattar M. Omar, Jeddah, SA;
Assignee:
KING ABDULAZIZ UNIVERSITY, Jeddah, SA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 31/505 (2006.01); A61K 9/127 (2006.01); A61K 31/40 (2006.01); A61K 31/44 (2006.01); A61K 31/366 (2006.01); A61K 31/47 (2006.01); A61K 31/22 (2006.01); A61K 31/405 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5161 (2013.01); A61K 9/127 (2013.01); A61K 9/1271 (2013.01); A61K 9/5123 (2013.01); A61K 31/22 (2013.01); A61K 31/366 (2013.01); A61K 31/40 (2013.01); A61K 31/405 (2013.01); A61K 31/44 (2013.01); A61K 31/47 (2013.01); A61K 31/505 (2013.01); Y10S 977/773 (2013.01); Y10S 977/906 (2013.01); Y10S 977/907 (2013.01);
Abstract
Chitosan-coated, flexible lipid-based nanoparticles are provided. The nanoparticles ('chitoplexes') comprise an interior comprising a mixture of a phospholipid, an edge activator, a charge inducing agent, and a statin; and an exterior chitosan coating which encapsulates the interior mixture. The chitoplexes exhibit enhanced bioavailability with respect to delivering the statins encapsulated therein to a subject, for example, for the treatment of cancer.