The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Apr. 28, 2021
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Reinhard Franze, Penzberg, DE;
Chikashi Hirashima, Tokyo, JP;
Thomas Link, Penzberg, DE;
Yoshinori Takagi, Tokyo, JP;
Shinya Takuma, Tokyo, JP;
Yuriko Tsuda, Tokyo, JP;
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
Herein is reported a method for the production of an immunoglobulin comprising the following steps: a) providing a eukaryotic cell comprising a nucleic acid encoding the immunoglobulin, b) cultivating the eukaryotic cell in a cultivation medium wherein the amount of glucose available in the cultivation medium per time unit is kept constant and limited to less than 80% of the amount that could maximally be utilized by the cells in the cultivation medium per time unit, and c) recovering the immunoglobulin from the culture.