The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 05, 2021

Filed:

Feb. 13, 2017
Applicant:

Corning Incorporated, Corning, NY (US);

Inventors:

Sumitava De, Painted Post, NY (US);

Yulong Hong, Painted Post, NY (US);

Nikolaos Pantelis Kladias, Horseheads, NY (US);

Shawn Michael O'Malley, Horseheads, NY (US);

Aravind Raghavan Rammohan, Big Flats, NY (US);

Po Ki Yuen, Painted Post, NY (US);

Assignee:

Corning Incorporated, Corning, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/00 (2006.01); C12M 1/04 (2006.01); C12M 1/00 (2006.01); C12M 1/06 (2006.01); C12M 1/12 (2006.01);
U.S. Cl.
CPC ...
C12M 29/10 (2013.01); C12M 23/20 (2013.01); C12M 23/24 (2013.01); C12M 23/26 (2013.01); C12M 23/34 (2013.01); C12M 27/02 (2013.01); C12M 29/04 (2013.01); C12M 29/06 (2013.01); C12M 29/20 (2013.01); C12M 37/02 (2013.01);
Abstract

A perfusion bioreactor and a method for using the perfusion bioreactor for performing a continuous cell culture are disclosed. The perfusion bioreactor includes an outer vessel having a housing with a gas permeable membrane, an opening and a cavity; an inner vessel within the cavity; and a lid to cover the opening. A porous membrane within the cavity divides the cavity into inner and outer compartments. A fresh media port extends through the outer vessel or the at least one lid to receive a fresh media tube that has an end located in the inner compartment. A spent media port extends through the outer vessel or the at least one lid to receive a spent media tube that has an end located in the outer compartment. A mixer is within the inner compartment, and the porous membrane is attached to an opening within the inner vessel.


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