The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Oct. 18, 2018
Novarts Ag, Basel, CH;
Michael DiDonato, San Diego, CA (US);
Bernhard Hubert Geierstanger, Solana Beach, CA (US);
Tobias Junt, Liestal, CH;
Mark Knuth, El Cajon, CA (US);
Shelly Meeusen, San Diego, CA (US);
Carolina Nicole Simpson, Chula Vista, CA (US);
Glen Spraggon, San Diego, CA (US);
John Trauger, Cambridge, MA (US);
Novartis AG, Basel, CH;
Abstract
The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.