The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Feb. 20, 2018
Applicant:
Cytiva Bioprocess R&d Ab, Uppsala, SE;
Inventors:
Gustav Rodrigo, Uppsala, SE;
Mats Ander, Uppsala, SE;
Tomas Bjorkman, Uppsala, SE;
Goran Bauren, Uppsala, SE;
Assignee:
Cytiva BioProcess R&D AB, Uppsala, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/31 (2006.01); B01D 15/38 (2006.01); B01J 20/286 (2006.01); B01J 20/32 (2006.01); C07K 1/22 (2006.01); C07K 14/745 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/31 (2013.01); B01D 15/3809 (2013.01); B01J 20/286 (2013.01); B01J 20/3204 (2013.01); B01J 20/3212 (2013.01); B01J 20/3219 (2013.01); B01J 20/3274 (2013.01); C07K 1/22 (2013.01); C07K 14/745 (2013.01); C07K 16/00 (2013.01);
Abstract
The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain ofProtein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 9 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.