The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Oct. 16, 2018
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Peter Kwong, Washington, DC (US);
John Mascola, Rockville, MD (US);
Gwo-Yu Chuang, Rockville, MD (US);
Hui Geng, Rockville, MD (US);
Yongping Yang, Potomac, MD (US);
Cheng Cheng, Bethesda, MD (US);
Jeffrey Boyington, Clarksburg, MD (US);
Yen-Ting Lai, Bethesda, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/005 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/21 (2006.01); C12N 7/00 (2006.01); C07K 14/16 (2006.01); A61K 39/39 (2006.01);
U.S. Cl.
CPC ...
C07K 14/162 (2013.01); A61K 39/12 (2013.01); A61K 39/39 (2013.01); A61K 2039/64 (2013.01);
Abstract
Immunogens comprising a recombinant HIV-1 Env ectodomain trimer stabilized in a prefusion closed conformation and methods of their use and production are disclosed. In several embodiments, the immunogen can be used to elicit an immune response to HIV-1 in a subject.