The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Jun. 30, 2017
Applicant:
Eisai R&d Management Co., Ltd., Tokyo, JP;
Inventors:
Charles E. Chase, Londonderry, NH (US);
Hyeong-Wook Choi, Andover, MA (US);
Atsushi Endo, Andover, MA (US);
Francis G. Fang, Andover, MA (US);
Dae-Shik Kim, Andover, MA (US);
Assignee:
EISAI R&D MANAGEMENT CO., LTD., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 493/22 (2006.01);
U.S. Cl.
CPC ...
C07D 493/22 (2013.01);
Abstract
The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.