The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 05, 2021

Filed:

May. 07, 2020
Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Kyle Bradley Pascual Clagg, San Francisco, CA (US);

Nicholas Andrew White, San Francisco, CA (US);

Haiming Zhang, San Mateo, CA (US);

Francis Gosselin, San Mateo, CA (US);

William Nack, Glenview, IL (US);

Paul D. O'Shea, Princeton, NJ (US);

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07F 9/24 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07F 9/2454 (2013.01);
Abstract

A method of synthesizing comprising a step of making an imidazo-pyrimidine compound by coupling a first compound of formula (II) with a second compound of formula (III) Followed by a deprotection and tosylation step. The methods are able to produce an isotopically substituted molecule having upwards of 95% purity relative to non-isotopically substituted molecules. The invention further comprises compounds of formula:


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