The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 05, 2021

Filed:

Aug. 08, 2019
Applicant:

Thetis Pharmaceuticals Llc, Branford, CT (US);

Inventors:

Frank C. Sciavolino, Waterford, CT (US);

Gary Mathias, Ridgefield, CT (US);

Michael C. Van Zandt, Guilford, CT (US);

Gunnar Erik Jagdmann, Jr., Branford, CT (US);

Jessica J. Dworak, Middletown, CT (US);

Assignee:

Thetis Pharmaceuticals LLC, Ridgefield, CT (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/54 (2017.01); A61K 47/62 (2017.01); C07C 59/42 (2006.01); C07C 229/26 (2006.01); C07C 237/12 (2006.01); C07C 237/22 (2006.01); A61P 1/06 (2006.01); A61P 1/12 (2006.01); A61P 29/00 (2006.01); A61P 1/04 (2006.01); A61K 31/202 (2006.01); A61K 31/232 (2006.01); A61K 38/03 (2006.01); A61K 45/06 (2006.01); A61P 1/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/541 (2017.08); A61K 31/202 (2013.01); A61K 31/232 (2013.01); A61K 38/03 (2013.01); A61K 45/06 (2013.01); A61K 47/62 (2017.08); A61P 1/00 (2018.01); A61P 1/04 (2018.01); A61P 1/06 (2018.01); A61P 1/12 (2018.01); A61P 29/00 (2018.01); C07C 59/42 (2013.01); C07C 229/26 (2013.01); C07C 237/12 (2013.01); C07C 237/22 (2013.01); A61K 2800/00 (2013.01);
Abstract

The present invention relates to compounds of Formulas I-IV and compositions comprising same, including pharmaceutical compositions. The compounds of Formulas I-IV represent new salt forms of specialized pro-resolving mediators ('SPMs') which include lipoxins, resolvins, protectins, and their aspirin-triggered counterparts. The SPM salts described here contain at least one or two SPM molecules ionically bound to at least one basic function that is provided by a scaffold as described in Formulas I-IV. Also provided are methods for pharmaceutical and non-pharmaceutical uses of such compounds and compositions describing same.


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