The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Jan. 08, 2019
Applicant:
Realta Holdings, Llc, Norfolk, VA (US);
Inventors:
Neel K. Krishna, Norfolk, VA (US);
Kenji Cunnion, Norfolk, VA (US);
Assignee:
REALTA HOLDINGS, LLC, Norfolk, VA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/43 (2006.01); A61P 37/06 (2006.01); A61K 47/10 (2017.01); A61K 9/00 (2006.01); A61K 38/08 (2019.01); C07K 14/47 (2006.01); C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
A61K 38/43 (2013.01); A61K 9/0019 (2013.01); A61K 38/005 (2013.01); A61K 38/08 (2013.01); A61K 47/10 (2013.01); A61P 37/06 (2018.01); C07K 14/005 (2013.01); C07K 14/4703 (2013.01); C12N 2770/00022 (2013.01); C12N 2770/00033 (2013.01);
Abstract
A method of treating systemic lupus erythematosus in a subject is provided in which a therapeutically effective amount of PIC1 is administered to the subject. A method of treating transfusion-related acute lung injury is also provided where a therapeutically effective amount of PIC1 is administered to the subject. PIC1 can modulate immune complex activation of the complement system and NET formation in the subject. PIC1 can also inhibit myeloperoxidase (MPO) activity in the subject.