The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 05, 2021

Filed:

Dec. 11, 2014
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Patricia K. Donahoe, Boston, MA (US);

David Pepin, Somerville, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/22 (2006.01); A61K 38/17 (2006.01); A61P 15/18 (2006.01); A61P 15/08 (2006.01); A61K 9/00 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/22 (2013.01); A61K 9/0019 (2013.01); A61K 38/17 (2013.01); A61P 15/08 (2018.01); A61P 15/18 (2018.01); C12N 7/00 (2013.01); C12N 2750/14142 (2013.01); C12N 2750/14171 (2013.01);
Abstract

One aspect of the invention provides a method of contraception by administering to a female subject a composition comprising Mullerian inhibiting substance (MIS). The MIS can be produced endogenously in the subject by a vector, where the vector comprises a polynucleotide encoding a recombinant MIS protein. In some embodiments, the contraception is permanent and only requires administration of the composition once. Another aspect of the invention relates to a method of preserving an ovarian reserve, the method comprising administering to a female subject a composition comprising MIS or an inducible vector that comprises a polynucleotide encoding a recombinant MIS protein.


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