The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Mar. 29, 2018
Applicants:
University of Houston System, Houston, TX (US);
Trustees of Tufts College, Medford, MA (US);
Inventors:
Gregory Cuny, Houston, TX (US);
Chalada Suebsuwong, Houston, TX (US);
Alexei Degterev, Brookline, MA (US);
Assignees:
University of Houston System, Houston, TX (US);
Trustees of Tufts College, Medford, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/00 (2006.01); A61K 31/444 (2006.01);
U.S. Cl.
CPC ...
A61K 31/444 (2013.01);
Abstract
Identified compounds demonstrate protein kinase inhibitory activity and inhibition of dependent cell signaling pathways, such as NOD2 cell signaling. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.