The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Sep. 11, 2018
Enzychem Lifesciences Corporation, Daejeon, KR;
Korea Research Institute of Bio Science and Biotechnology, Daejeon, KR;
Sei-Ryang Oh, Daejeon, KR;
Kyung Seop Ahn, Daejeon, KR;
Su Ui Lee, Daejeon, KR;
In Sik Shin, Daejeon, KR;
Na-Rae Shin, Daejeon, KR;
Tae-Suk Lee, Daejeon, KR;
JongKoo Kang, Chungcheongbuk-do, KR;
Young-Sik Jung, Seoul, KR;
Yong-Hae Han, Seoul, KR;
Ki Young Sohn, Seoul, KR;
Enzychem Lifesciences Corporation, Seoul, KR;
Abstract
The present invention relates to a pharmaceutical composition containing a monoacetyldiacyiglycerol compound as an active ingredient for preventing or treating asthma, and a functional health food composition for preventing or treating asthma. The monoacetyldiacylglycerol compound of the present invention inhibits the expression of IL-4 in EL-4 cells, which are mouse T cell lymphoma cells, reduces hypersensitivity of airway in an asthma-induced animal model, and inhibits the infiltration of inflammatory cells into the bronchial tube. In addition, the compounds of the present invention inhibit the generation of IgE in the serum and bronchoalveolar lavage fluid, have an excellent effect of inhibiting the expression of Th2 cytokines (IL-4, IL-5, and IL-13) in the lung, thereby overcome side effects of the currently used therapeutic agents for asthma, have no toxicity, and exhibit a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating asthma.