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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11135186 B1

PDFFull Text
Date of Patent:
Oct. 05, 2021

Filed:

Dec. 29, 2016

Regulators of the endoplasmic reticulum proteostasis network

Applicant:

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Christina Cooley, San Antonio, TX (US);

Jeffery W. Kelly, Solana Beach, CA (US);

Ryan Paxman, San Diego, CA (US);

Lars Plate, San Diego, CA (US);

R. Luke Wiseman, Chula Vista, CA (US);

Assignee:

The Scripps Research Institute, La Jolla, CA (US);

Attorneys:

Rimon, P.C.

Dale L. Rieger

Primary Examiner:

Anna Pagonakis

Int. Cl.
CPC ...
A61K 31/167 (2006.01); A61K 31/506 (2006.01); A61K 31/381 (2006.01); A61K 31/415 (2006.01); A61K 31/4184 (2006.01); A61K 31/42 (2006.01); A61K 31/422 (2006.01); A61K 31/428 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/497 (2006.01); A61K 31/4245 (2006.01); A61K 31/47 (2006.01); A61K 31/4196 (2006.01); A61K 31/53 (2006.01); A61K 31/4178 (2006.01); A61K 31/137 (2006.01); A61K 31/50 (2006.01); A61K 31/4174 (2006.01); A61K 31/136 (2006.01); A61K 31/429 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
A61K 31/167 (2013.01); A61K 31/136 (2013.01); A61K 31/137 (2013.01); A61K 31/381 (2013.01); A61K 31/415 (2013.01); A61K 31/4174 (2013.01); A61K 31/4178 (2013.01); A61K 31/4184 (2013.01); A61K 31/4196 (2013.01); A61K 31/42 (2013.01); A61K 31/422 (2013.01); A61K 31/428 (2013.01); A61K 31/429 (2013.01); A61K 31/4245 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/47 (2013.01); A61K 31/497 (2013.01); A61K 31/50 (2013.01); A61K 31/506 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01);
Abstract

The invention provides compounds for activating the activating transcription factor 6 (ATF6) arm of the unfolded protein response (UPR), or activating the transcriptional targets of ATF6, in the endoplasmic reticulum of a cell, the compounds being of any of formulas (I) through (IX) as described herein. The compounds can be used for treatment of conditions involving gain-of-toxic-function and loss-of-function folding disorders including lysosomal storage diseases, antitrypsin-associated emphysema and similar diseases. These molecules are also expected to have disease-ameliorating effects in Alzheimer's disease and diabetes.

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