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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11131673 B1

PDFFull Text
Date of Patent:
Sep. 28, 2021

Filed:

Apr. 27, 2018

Live single-cell bioassay in microdroplets

Applicant:

Northeastern University, Boston, MA (US);

Inventors:

Tania Konry, Boston, MA (US);

Saheli Sarkar, Boston, MA (US);

Pooja Sabhachandani, Boston, MA (US);

Assignee:

Northeastern University, Boston, MA (US);

Attorney:

Verrill Dana, LLP

Primary Examiner:

Changhwa J Cheu

Int. Cl.
CPC ...
G01N 33/574 (2006.01); B01L 3/02 (2006.01); G01N 21/64 (2006.01); G01N 33/557 (2006.01); G01N 35/08 (2006.01); G01N 1/36 (2006.01); G01N 33/50 (2006.01); G01N 15/14 (2006.01); G01N 15/00 (2006.01); B01L 3/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57492 (2013.01); B01L 3/0241 (2013.01); B01L 3/502761 (2013.01); B01L 3/502784 (2013.01); G01N 1/36 (2013.01); G01N 21/6408 (2013.01); G01N 21/6458 (2013.01); G01N 33/5091 (2013.01); G01N 33/557 (2013.01); G01N 35/08 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/0673 (2013.01); B01L 2300/0816 (2013.01); B01L 2400/0424 (2013.01); G01N 15/147 (2013.01); G01N 15/1484 (2013.01); G01N 2015/008 (2013.01); G01N 2015/1481 (2013.01); G01N 2800/52 (2013.01); G01N 2800/56 (2013.01); G01N 2800/7028 (2013.01);
Abstract

Bioassays are provided for detecting and analyzing responses from single cells and cell pairs suspended in micro-scale droplets (80-200 μm diameter) generated in microfluidic devices. Cell responses to various stimuli are analyzed. The stimuli are delivered by homotypic or heterotypic cells, small molecule drugs, and therapeutic agents including immunotherapeutics. The bioassays can be used to describe heterogeneity in any given cell population, and can be used in a clinical setting, such as profiling of patient-derived cells, designing personalized treatment strategies, and optimizing drug combinations for immunotherapy of tumors.

Find Patent Forward Citations

Konry, Tania. (2021). Live single-cell bioassay in microdroplets (U.S. Patent No. 11131673). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11131673

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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