The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2021
Filed:
May. 31, 2018
Applicant:
Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);
Inventors:
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/74 (2006.01); A61K 39/39 (2006.01); C07K 14/195 (2006.01); C12N 9/10 (2006.01); C12P 19/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/743 (2013.01); A61K 39/39 (2013.01); C07K 14/195 (2013.01); C12N 9/1029 (2013.01); C12P 19/12 (2013.01); A61K 2039/55572 (2013.01);
Abstract
The present invention relates to the fields of genetically modifiedstrains, vaccine adjuvants, and generally molecular biology and immunology. Provided herein are modifiedstrains that produce lipopolysaccharide (LPS) having reduced toxicity or detoxified lipopolysaccharide, and methods of obtaining such strains for plant-based production of biologies. Also provided herein are uses of reduced or detoxified LPS as adjuvants suitable for clinical use.