The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2021
Filed:
Aug. 04, 2016
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventors:
Birgit Piater, Darmstadt, DE;
Ulrich Betz, Reinheim, DE;
Harald Kolmar, Muehltal, DE;
Vanessa Siegmund, Darmstadt, DE;
Assignee:
MERCK PATENT GMBH, Darmstadt, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/30 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); C07K 16/00 (2013.01); C07K 16/2863 (2013.01); C07K 2317/24 (2013.01); C07K 2317/54 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01);
Abstract
The present invention provides novel peptide sequences for use in microbial transgluatminase-mediated, in particular mTG2-mediated bioconjugations, in particular for the manufacture of antibody-drug-conjugates. Further disclosed are bioconjugation methods employing mTG2 and the novel peptide sequence motifs of the invention. The present invention further provides proteins comprising the novel sequence motifs of the invention as well as polynucleotides encoding the same.