The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2021
Filed:
Oct. 09, 2019
Tilos Therapeutics, Inc., Rahway, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Randall Burton, Billerica, MA (US);
Jessie M. English, Cambridge, MA (US);
Barbara S. Fox, Wayland, MA (US);
Stavros Kopsiaftis, West Roxbury, MA (US);
Renee Moore, Medway, MA (US);
Patricia Rao, Acton, MA (US);
Kenneth J. Simon, Milton, MA (US);
Tilos Therapeutics, Inc., Rahway, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGFβ1 on cells but not to LAP-TGFβ1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.